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¿Qué medicamentos no deben tomarse con Biktarvy?

essential points

  • biktarvy (bictegravir, emtricitabine and tenofovir alafenamide) is actually a dental, 3-drug combination pill used to address immunodeficiency virus type 1 (hiv-1). biktarvy is a total routine as well as its utilize along with other antiretroviral medicines for the treatment of hiv-1 infection isnt suggested.
  • biktarvy is actually connected with numerous drug-drug and drug-food relationships since it consists of three different medications, boosting your threat for connections. no one should get biktarvy with dofetilide (tikosyn), a drug useful heart flow conditions or rifampin (rifadin), a medicine for tuberculosis (tb). these medications tend to be contraindicated with the use of biktary. (see table 1).
  • it is essential having a family doctor or pharmacist examine the treatments for feasible drug communications every time you begin if not stop a unique prescription, over-the-counter or herbal medication or diet supplement.
  • biktarvy may also create problems for those who have specific medical ailments. eg, the liver infection particularly hepatitis, renal illness, and specific bone tissue diseases like osteoporosis may be suffering from biktarvy.

exactly what are medication connections?

anytime you take a medication and mix it along with other drugs, or specific foods, refreshments, over-the-counter (otc) medicines, or herbal medicines you happen to be prone to a drug conversation.

many medicine interactions are not significant; however, some are very its crucial that you understand the feasible result before you combine medications with other drugs, alcoholic beverages, particular foods or other chemicals.

the more treatments you adopt, the higher the opportunity for the medication interacting with another medication or substance. drug-drug communications can decrease how good your drugs work, may increase minor or really serious unexpected side effects, and sometimes even boost the bloodstream amount and poisoning of a certain medicine.

lots of medicine connections, such as those with biktarvy, occur if an individual medication impacts another drug’s intake through the stomach or bowel, distribution for the human body, kcalorie burning (digest) within the the liver, or excretion through kidneys.

drug interactions can be complicated, particularly if you simply take a few medicines, very usually check with your doctor.

drug interactions with biktary

drug relationships with biktarvy can result in several results, such as:

  • loss of the intended restorative effect
  • increased danger of significant adverse side effects from elevated bloodstream quantities of drugs
  • need to regulate the dose or dosing interval of biktarvy or make use of alternate medicines

notice: there are numerous various other feasible medication interactions with biktary. have your physician or pharmacist screen for medicine relationships each time you start – if not stop – a medication. discuss these selected drug communications with your healthcare service providers.

table 1: particular biktarvy medicine interactions

medicine of concern outcome action

*table just isnt including all feasible drug communications.

anticonvulsants: carbamazepine, oxcarbazepine, phenobarbital phenytoin reduced bictegravir and tenofovir alafenamide bloodstream amounts  biktarvy should-be used with renewable anticonvulsants.
dofetilide (tikosyn) – a drug useful for irregular heart beats improved dofetilide blood amounts with serious, deadly side effects. do not use with biktarvy (contraindicated)
rifampin – useful for tb therapy diminished bloodstream degrees of bictegravir and tenofovir alafenamide, which may decrease efficiency for hiv and result in viral resistance. avoid using with biktarvy (contraindicated because of bictegravir part).
rifabutin, rifapentine reduced blood degrees of bictegravir, which might reduce efficiency for hiv and trigger viral weight. utilize with rifabutin or rifapentine isnt suggested.
st. john’s wort – natural supplement usually employed for despair diminished blood levels of bictegravir and tenofovir alafenamide, which might decrease efficiency for hiv and result in viral weight. coadministration with st. john’s wort just isnt suggested.
products or medications containing magnesium (mg), aluminum (al), calcium (ca) and iron (fe)  (such as some antacids, laxatives, sucralfate, and buffered drugs). decreased consumption and blood amounts of bictegravir, which might reduce effectiveness for hiv and result in viral weight.

antacids that contain al/mg

for antacids which contain aluminum or magnesium, just take biktavry no less than 2 hours before or 6 hours after youre taking these antacids.

schedule administration of biktarvy collectively with, or 2 hours after you are taking antacids that contain al / mg isnt advised. 

health supplements or antacids containing calcium or iron

if you take health supplements or antacids that have iron or calcium, get biktarvy with food during the ​same time which you grab these products or antacids.  

it is far from recommended you routinely grab biktarvy with calcium supplements or metal supplements on an empt​y belly. taking biktarvy on an empty belly with ca or fe products, or up to couple of hours once youve taken the products, is certainly not recommended.

metformin improved metformin and tenofovir alafenamide bloodstream degrees. confer with your doctor. you will need a dose modification if you are receiving metformin.

certain enzymes and transporters present your body, typically within renal or liver, could affect your medicine therapy. your pharmacist or medical practitioner can verify for any medications affecting these compounds which will change your own a reaction to biktarvy or any other medicines. these include:

  • natural cation transporter 2 (oct2)
  • multidrug and contaminant extrusion transporter 1 (mate1)
  • cytochrome p450 3a (cyp3a)
  • udp-glucuronosyltransferase 1a1 (ugt1a1)
  • p-glycoprotein (p-gp)
  • breast cancer resistance protein (bcrp)

because emtricitabine and tenofovir, two aspects of biktarvy, are mainly excreted by your kidneys, utilization of biktarvy with medicines that affect renal function may increase levels of emtricitabine, tenofovir, as well as other medications which go through the renal. this might boost the risk of negative effects.

examples of medicines which can be influenced feature, acyclovir, cidofovir, ganciclovir, valacyclovir, valganciclovir, aminoglycosides (e.g., gentamicin), and high-dose or numerous nonsteroidal antiinflammatory medications (nsaids) such as for instance ibuprofen or naproxen.

the producer of biktarvy notes that no medically significant medicine interactions happen noticed whenever biktarvy is coupled with:

  • ethinyl estradiol
  • ledipasvir/sofosbuvir
  • midazolam
  • norgestimate
  • sertraline
  • sofosbuvir
  • sofosbuvir/velpatasvir
  • sofosbuvir/velpatasvir/voxilaprevir

review these, and various other potential biktarvy medicine communications when you look at the drug communication checker.

what health conditions tend to be a problem if i simply take biktarvy?

drug relationships don’t constantly take place in just some other drugs or meals. your health conditions can impact biktavry, as well.

for instance, if you really have continuous liver, kidney or bone tissue condition you are at higher threat of worsening these problems once you grab biktarvy. tell your medical practitioner if any of these conditions impact you.

there are numerous infection relationships with biktarvy including:

  • liver (hepatic) illnesses, including hepatitis b trojan (hbv)
  • kidney (renal) impairment
  • hemodialysis
  • bone toxicity particularly osteoporosis

other significant side effects for biktarvy, which can affect these problems, consist of:

  • immunity changes
  • kidney issues, such as kidney failure
  • liver dilemmas, which might hardly ever induce demise (rare)
  • too a lot lactic acid within blood generally lactic acidosis (rare)

kidney infection

biktarvy is not advised in clients with extreme renal impairment (estimated crcl <30 ml/min) or serious hepatic impairment (child-pugh course c). your medical professional can see whether you have kidney impairment with tests.

inform your doctor straight away if any brand new or worsening unwanted effects happen. tell your medical practitioner straight away if you get these signs and symptoms, which might be an indication of lactic acidosis:

  • weakness or being more tired than usual
  • unexpected muscle pain
  • shortness of air, fast breathing
  • stomach pain with nausea and vomiting
  • cold or blue hands and feet
  • feeling dizzy or lightheaded
  • fast or irregular heartbeat

hepatitis b (hbv) disease and liver toxicity

biktarvy may worsen hepatitis b (hbv) illness. if you have both hiv-1 and hbv preventing getting biktarvy, the hbv may out of the blue come to be even worse. try not to prevent taking biktarvy without initial talking-to your medical provider, as they begin to need to keep track of your health.

inform your physician quickly if you get any of these signs, which might be an indication of the liver toxicity:

  • skin or perhaps the white element of the eyes converts yellow
  • dark “tea-colored” urine
  • light-colored stools
  • loss of appetite for a couple of days or much longer, nausea
  • pain in your own belly area

how is biktary utilized?

biktarvy, from gilead, is actually a dental, 3-drug combination pill regularly treat immunodeficiency virus sort 1 (hiv-1). it contains the integrase strand move inhibitor (insti) bictegravir, combined with the nucleoside analogue reverse transcriptase inhibitors (nrtis) emtricitabine (ftc) and tenofovir alafenamide (taf).

biktarvy was fda-approved in feb. 2018 as a whole regime to treat hiv-1 infection in grownups and kids evaluating at the least 25 kg (55 lbs):

  • who possess no antiretroviral therapy history or,
  • to replace the current antiretroviral routine in some clients.

biktarvy is taken daily, daily, with or without food.  biktarvy is actually taken by itself (maybe not together with other hiv-1 medications) to deal with hiv-1 infection. its considered a whole regime in one medicine. do not overlook any doses.

the most frequent unwanted effects you will knowledge about biktary consist of:

  • diarrhoea (occurring in 6percent, or 6 from every 100 customers)
  • nausea (occurring in 6percent, or 6 out of each and every 100 clients)
  • headache (occurring in 5per cent, or 5 from every 100 clients)

bottom line

biktarvy contains three different drugs familiar with address hiv-1, and this can greatly increase your threat for a drug communicating. (see table 1)

only a few medicine communications tend to be severe, many could be, it is therefore important to have analysis medicine interactions any time you start or end a medication. discover numerous possible drug connections with biktarvy, and never all biktarvy medication interactions are listed in this review.

usually have your medical professional or pharmacist review for feasible drug communications each time you begin or end a medication. discuss these selected medicine relationships along with your healthcare providers. never ever stop a medication without speaking with your physician 1st.

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